Investigators at Helfgott conducted numerous studies and published 24 peer-reviewed papers in 2022, providing continued high-quality research in the field of integrative health. Below are the details of each 2019 study and links to the published work.

Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL; Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias. Alzheimer’s Dement. 2022 Dec 8. doi: 10.1002/alz.12845. Epub ahead of print. PMID: 36479795

Calder PC, Ortega EF, Meydani SN, Adkins Y, Stephensen CB, Thompson B, Zwickey H. Nutrition, Immunosenescence, and Infectious Disease: An Overview of the Scientific Evidence on Micronutrients and on Modulation of the Gut Microbiota. Adv Nutr. 2022 Oct 2;13(5):S1-S26. doi: 10.1093/advances/nmac052. PMID: 36183242

Guedry SE, Langley BO, Schaefer K, Hanes DA. Patient experience of chronic illness care and complementary integrative health use: a cross-sectional study of patients with hypermobility spectrum disorders (HSD) and Ehlers-Danlos syndromes (EDS). Disabil Rehabil. 2022 Oct 12:1-11. doi: 10.1080/09638288.2022.2131003. Epub ahead of print. PMID: 36222285.

Langley BO, Ryan JJ, Phipps J, Buttolph L, Bray B, Aslan JE, Metz TO, Stevens JF, Bradley R. Xanthohumol microbiome and signature in adults with Crohn’s disease (the XMaS trial): a protocol for a phase II triple-masked, placebo-controlled clinical trial. Trials. 2022 Oct 22;23(1):885. doi: 10.1186/s13063-022-06782-z. PMID: 36273173

Nakama C, Thompson B, Szybala C, McBeth A, Dobner P, Zwickey H. The Continuum of Microbial Ecosystems along the Female Reproductive Tract: Implications for Health and Fertility. Pathogens. 2022 Oct 27;11(11):1244. doi: 10.3390/pathogens11111244. PMID: 36364994

Vita AA, Pullen NA. Exploring the mechanism of berberine-mediated Tfh cell immunosuppression. Phytomedicine. 2022 Oct;105:154343. doi: 10.1016/j.phymed.2022.154343. Epub 2022 Jul 15. PMID: 35901597

Bray B, Bray C, Bradley R, Zwickey H. Mental health aspects of binge eating disorder: A cross-sectional mixed-methods study of binge eating disorder experts’ perspectives. Front Psychiatry. 2022 Sep 15;13:953203. doi: 10.3389/fpsyt.2022.953203. PMID: 36186859

Hanes D, Nowinski B, Lamb JJ, Larson IA, McDonald D, Knight R, Song SJ, Patno N. The gastrointestinal and microbiome impact of a resistant starch blend from potato, banana, and apple fibers: A randomized clinical trial using smart caps. Front Nutr. 2022 Sep 29;9:987216. doi: 10.3389/fnut.2022.987216. PMID: 36245486

McClure C, Bollen M, Buttolph Stack LE, Langley BO, Hanes D, Wright KM, Tibbitts D, Bradley R. Safety and tolerability of Pau d′ Arco (Tabebuia avellanedae) for primary dysmenorrhea: A single-arm, open-label trial on adults ages 18–45. Advances in Integrative Medicine. 2022 September 9:3 159-66. doi.org/10.1016/j.aimed.2022.04.003

Vita AA, Zwickey H, Bradley R. Associations between food-specific IgG antibodies and intestinal permeability biomarkers. Frontiers in Nutrition. 2022 September 6; 9. Doi: 10.3389/fnut.2022.962093. PMID: 36147305

Fitzgerald KN, Hodges R, Hanes D, Stack E, Cheishvili D, Szyf M, Henkel J, Twedt MW, Giannopoulou D, Herdell J, Logan S, Bradley R. Correction for: Potential reversal of epigenetic age using a diet and lifestyle intervention: a pilot randomized clinical trial. Aging (Albany NY). 2022 Jul 27;14(14):5959. doi: 10.18632/aging.204197. Epub 2022 Jul 27. Erratum for: Aging (Albany NY). 2021 Apr 12;13(7):9419-9432. PMID: 35907207

Steel A, Redmond R, Schloss J, Cramer H, Goldenberg J, Leach MJ, Harnett JE, Van de Venter C, McLintock A, Bradley R, Hawrelak J, Cooley K, Leung B, Adams J, Wardle J. International prevalence of consultation with a naturopathic practitioner: a systematic review and meta-analysis. BMJ Open. 2022 Jul 25;12(7):e056075. doi: 10.1136/bmjopen-2021-056075. PMID: 35879017

Wexler RS, Fox DJ, Edmond H, Lemau J, ZuZero D, Bollen M, Montenegro D, Parikshak A, Thompson AR, Carlson NL, Carlson HL, Wentz AE, Bradley R, Hanes DA, Zwickey H, Pickworth CK. Protocol for mindfulness-oriented recovery enhancement (MORE) in the management of lumbosacral radiculopathy/radiculitis symptoms: A randomized controlled trial. Contemp Clin Trials Commun. 2022 Jul 3;28:100962. doi: 10.1016/j.conctc.2022.100962. PMID: 35812821

Pacheco LS, Bradley RD, Anderson CAM, Allison MA. Changes in Biomarkers of Non-Alcoholic Fatty Liver Disease (NAFLD) upon Access to Avocados in Hispanic/Latino Adults: Secondary Data Analysis of a Cluster Randomized Controlled Trial. Nutrients. 2022 Jun 30;14(13):2744. doi: 10.3390/nu14132744. PMID: 35807924

Pasalar M, Tabatabaei F, Bradley R, Tajadini H, Kamali M, Hasheminasab FS, Parvizi MM. Mechanistic support of traditional Persian medicine for the treatment of acne vulgaris: A scoping review. J Cosmet Dermatol. 2022 Jun;21(6):2338-2348. doi: 10.1111/jocd.14464. Epub 2021 Sep 26. PMID: 34564932

Bray B, Bray C, Bradley R, Zwickey H. Binge Eating Disorder Is a Social Justice Issue: A Cross-Sectional Mixed-Methods Study of Binge Eating Disorder Experts’ Opinions. Int J Environ Res Public Health. 2022 May 20;19(10):6243. doi: 10.3390/ijerph19106243. PMID: 35627779;

Myers TR, Saul B, Karlsen M, Beauchesne A, Glavas Z, Ncube M, Bradley R, Goldhamer AC. Potential Effects of Prolonged Water-Only Fasting Followed by a Whole-Plant-Food Diet on Salty and Sweet Taste Sensitivity and Perceived Intensity, Food Liking, and Dietary Intake. Cureus. 2022 May 3;14(5):e24689. doi: 10.7759/cureus.24689. PMID: 35663685

Sadowski A, Wexler RS, Hanes D, Buttolph L, Torrens T, Moehle J, Sarrar H, Harnett J, Zava DT, Bradley R. Meditative practices, stress and sleep among students studying complementary and integrative health: a cross-sectional analysis. BMC Complement Med Ther. 2022 May 5;22(1):127. doi: 10.1186/s12906-022-03582-5. PMID: 35513823

Vita AA, McClure R, Farris Y, Danczak R, Gundersen A, Zwickey H, Bradley R. Associations between Frequency of Culinary Herb Use and Gut Microbiota. Nutrients. 2022 May 9;14(9):1981. doi: 10.3390/nu14091981. PMID: 35565947

Garofalo L, Nakama C, Hanes D, Zwickey H. Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection. Antibiotics (Basel). 2022 Feb 9;11(2):218. doi: 10.3390/antibiotics11020218. PMID: 35203820

Harnett JE, Rickwood C, Steel A, Bradley R. Naturopathic practitioners’ approach to caring for people with cardiovascular disease risk factors: A cross-cultural cross-sectional study reporting the providers perspective. Complement Ther Clin Pract. 2022 Feb;46:101511. doi: 10.1016/j.ctcp.2021.101511. Epub 2021 Nov 7. PMID: 34768132.

Heiran A, Bagheri Lankarani K, Bradley R, Simab A, Pasalar M. Efficacy of herbal treatments for functional dyspepsia: A systematic review and meta-analysis of randomized clinical trials. Phytother Res. 2022 Feb;36(2):686-704. doi: 10.1002/ptr.7333. Epub 2021 Dec 1. PMID:34851546

Sadowski A, Garofalo L, Welsh A, Bradley R. Naturopathic Doctors: An Underutilized Resource of Whole Health Delivery in Primary Care. Glob Adv Health Med. 2022 Feb 22;11:2164957X221079787. doi: 10.1177/2164957X221079787. PMID: 35223196