Development of a Multicomponent Mindfulness and Movement Program for Lumbosacral Radiculopathy
Principal Investigator: Ryan Wexler, ND, MSCR (NUNM)
Co-Investigators and Collaborators: Ryan Bradley, ND, MPH (NUNM, USCD); Julie Fritz, PT, PhD, FAPTA (University of Utah); Anna Kratz, PhD (University of Michigan); Shabab Wahid, DrPH (George Mason University); (Anna Parisi, PhD (George Mason University); Anand Parikshak, BS (NUNM), Daniel Clauw, MD (University of Michigan); David Williams, PhD (University of Michigan); Steve Harte, PhD (University of Michigan); Hans Carlson, MD (OHSU); Scott Mist, PhD, MacOM (OHSU)
Research Assistants: Danica Shane, BS (NUNM); Giomary Castillo, BS (NUNM); Zewdi Cass, BS (OHSU); Vinz Lendof (PCC)
Funding: This study is funded through the grant: K12NS130673 from the National Institute of Neurological Disorders and Stroke.
This study aims to develop and test a multicomponent intervention that integrates mindfulness and physical activity for patients with lumbosacral radiculopathy (LR), more commonly known as “sciatica”. We will evaluate self-report measures of pain, disability, kinesiophobia, and other psychosocial factors related to chronic pain. To develop the intervention, we will conduct focus groups with LR patients and clinicians who treat LR. Participants may be recruited for involvement in a community advisory board that will oversee the conduct of a subsequent single-arm pilot trial to evaluate the feasibility of the intervention.
Remotely-delivered Yoga Nidra for Decreasing Use of BZRAs for Insomnia and Anxiety in Older Adults
Principal Investigator: Ryan Bradley, ND, MPH;
Co-Investigator: Erica Sharpe, PhD
We are investigating the effects of remote yoga nidra on tapering of benzodiazepine medications for sleep and anxiety in older adults. We will recruit 40 people for this six-week trial, during which time they will listen to yoga nidra or practice an education control 3-5x’s/week, and track their sleep, anxiety, medication use, as well as respiratory rate and pulse. We will additionally collect urine samples to objectively quantify BZRA use and tapering after the trial is complete.
Opinions and experiences of qigong from people with multiple sclerosis though focus groups
Principal Investigator: Lita Buttolph, PhD, DSOM, MS (NUNM)
Co-Investigators: Heather Zwickey, PhD (NUNM); Ryan Bradley, ND, MPH (NUNM); Lindsey Wooliscroft, MD, MS (OHSU); Gloria Yeh, MD, MS (Harvard); Jamie Villanueva, DAOM (UW); Heena Manglani, PhD (Harvard)
Research Assistant: Tanya Snyder, BS (NUNM)
The purpose of this study is to conduct focus groups of people with multiple sclerosis (MS) who practice qigong or tai chi to understand if and how they benefit from these practices, and to gather opinions about designing a qigong research study for people with MS. Aims include understanding how qigong can benefit people with MS who have a regular practice; characterizing forms that are safe, feasible and efficacious in improving MS symptoms; identifying key factors that promote effective learning and maximize benefits of qigong; and identifying key components necessary for conducting a clinical trial of qigong for MS.
Identifying key components of a qigong intervention for multiple sclerosis
Principal Investigator: Lita Buttolph, PhD, DSOM, MS (NUNM)
Co-Investigators: Heather Zwickey, PhD (NUNM); Ryan Bradley, ND, MPH (NUNM); Lindsey Wooliscroft, MD, MS (OHSU); Gloria Yeh, MD, MPH (Harvard); Jamie Villanueva, DAOM (UW); Tasha Parman, DPT (UW)
This study identifies key components of a qigong intervention for people with multiple sclerosis (MS) by surveying researchers, clinicians and qigong instructors with experience working with or teaching people with MS. Aims include identifying qigong forms, movements, and learning environments that are feasible, safe, and efficacious in improving motor and non-motor symptoms for people with MS. Results will be used to inform a clinical trial of qigong for MS.
Neurophysiological correlates of Sustained Interoceptive Awareness
Principal Investigator: Dana Dharmakaya Colgan, PhD
Co-PI: Cynthia Price, PhD
This study aims to investigate neurophysiological correlates of sustained interoceptive awareness and assess change within neurophysiological, psychophysiological, and self-reported variables during sustained interoceptive awareness with therapist-assisted touch, when compared without therapist-assisted touch. Results are expected to identify neurophysiological correlates of sustained interoceptive awareness in advanced meditators and inform the optimization of interoceptive training for maximal health benefits.
Preoperative Predictors of Postneurosurgical Pain Outcomes
Principal Investigator: Dana Dharmakaya Colgan, PhD
Co-PI: Katie Schenning, MD
This study aims to investigate modifiable preoperative predictors of postneurosurgical pain outcomes in older adults. Participants will undergo pre- and post-operative neurocognitive testing and interviews for functional and patient-reported outcomes, including interoceptive awareness and symptoms of central sensitization. Results are expected to inform future preoperative interventions to improve postneurosurgical pain outcomes among older adults.
Interoception and Cortical Reactivity in Response to Lab-Based Pain
Principal Investigator: Dana Dharmakaya Colgan, PhD
Co-PI: Barry Oken, MD, PhD
This study is investigating relationships among interoceptive awareness and neurophysiological processes (i.e., pain related evoked potentials) in response to lab-based pain. Results are expected to increase our understanding of the role of top-down processes of interoceptive awareness on central pain processing.
The Effect of Respiration Rate during Pranayama Practice on the Autonomic Nervous System and Endothelial Function
Principal Investigators: Erica Sharpe, PhD, Ryan Bradley, ND, MPH
Co-Investigators: Ben Zimmerman, PhD
We are currently building on our recent pranayama study (NCT#03280589), which investigated the impact of Sheetali and Sheetkari practices on heart rate variability (PMID: 34271528), by measuring effects of these practices on endothelial function (via EndoPAT device). This pilot trial will include n=6 participants and involves three breathing exercises (Sheetali, Sheetkari, and Deep Breathing). This work is an important investigation into the mechanistic effects of breathing practices used to maintain healthy blood pressure.