Epidemiology Research

Naturopathic management of post-acute sequelae of SARS-CoV-2 infection (i.e., “Long COVID”): A retrospective chart review

Principal Investigators: Ryan Bradley, ND, MPH (NUNM), Logan Rost, ND, MPH, CHES (My Family Health Centers).
Co-Investigators: Brendan Smith, ND (My Family Health Centers), Michelle Simon, ND, PhD (Institute of Natural Medicine), Jamie Corroon, ND, MPH (NUNM)

This study is a single-center retrospective case-series (n=15) performed at a rural, community clinic designed to characterize naturopathic treatments of post-acute sequelae of SARS-CoV-2 infection (i.e., “Long COVID”) and measure effect on symptom frequency, severity, and quality of life.

A Root Cause Approach to Post COVID Recovery, a Clinical Registry

Investigators: Jamie Corroon, ND, MPH (NUNM), Ryan Bradley, ND, MPH (NUNM), Laurie A Hoffman (Ovation Lab, Inc.), Patrick Hanaway, MD (AndHealth, Inc.)

This a patient registry which is designed to learn more about how individuals with post-acute sequelae SARS-CoV-2 infection (i.e., “Long COVID”) respond to a variety of therapeutic interventions (e.g., dietary supplements, dietary recommendations, etc.). Patients will be followed prospectively over 12-weeks and asked to complete a variety of questionnaires related to symptoms progression, treatment protocol adherence and adverse effects.

International Cohort on Lifestyle Determinants of Health

Principal Investigator: Ryan Bradley, ND, MPH

Students of complementary and alternative medicine have a unique set of lifestyle behaviors and health exposures. These behaviors and exposures have not been studied but represent a valuable source of data on health practices that are often outside the mainstream or may be in disagreement with conventional recommendations. The INCLD Health Study seeks to investigate associations between dietary, lifestyle, and educational exposures on health outcomes among adults exposed to complementary medicine education. Outcome measures include biometric measurements, cardiovascular markers, nutritional analysis, physical function, mood, sleep, and optional microbiome genomic sequencing.

Multi-Biomarker Exploration of SIBO: an Observational Study

Principal Investigator: Laurie Menk Otto, ND, MPH
Co-investigator: Diane Saunders, ND

Small intestine bacterial overgrowth (SIBO) is a syndrome in which one or more bacterial species exceed normal population levels, or bacteria that are not normally present in the small intestine colonize in large numbers. Common symptoms include diarrhea, flatulence, abdominal bloating and pain. The prevalence of SIBO in the general population has not been established, but it has been associated with a number of common conditions including irritable bowel syndrome, celiac disease, lactose intolerance, restless leg syndrome, acne rosacea, hypochlorhydria, hypothyroidism, Crohns disease and systemic sclerosis.

This study is the first to investigate the relationship between three factors that may contribute to SIBO: sensitivity to wide array of foods, gastrointestinal permeability and autoimmune conditions. The study measured and evaluated biomarkers specific to these factors from both SIBO positive and negative participants. The resulting data may improve future testing, treatment and resolution of SIBO. The study also evaluated how biomarkers correlate to participant diet, symptom severity, and previous history for known risk factors and associated diseases.

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